Per Nykrog, ‘Trois Contes’ comme vision d’histoire

Synaptic Ménage à Trois

Regulation of neurotransmitter receptor localization is critical for synaptic function and plasticity. In this issue of Neuron, Matsuda and colleagues (Matsuda et al., 2016) uncover a transsynaptic complex consisting of neurexin-3, C1q-like proteins, and kainate receptors that drives glutamate receptor clustering at hippocampal synapses.

Ménage à trois

Vision-Aided Acoustic Array Processing for Per- ceptive Environments

Motivation: Speech recognition software has advanced to the point where it can be employed as a mode of input in perceptive environments; however, current speech recognition techniques require low-noise signals to achieve resonable recognition rates. Such signals can be obtained from close-talking microphones, but we believe that it is possible to obtain similar signal quality from a large micr...

Ménage à trois

Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.

Stroke Risk Stratification in Patients With Atrial Fibrillation: Comme Ci, Comme Ça, Plus Ça Change….

T here has been a huge increase in academic interest in atrial fibrillation (AF) and particularly its major complication: thromboembolism. This sustained flurry of activity is fueled by the development of better thromboprophylaxis with well-controlled vitamin K antagonist (VKA) anticoagulation rather than antiplatelet therapy or poorly controlled management with VKAs. The emergence of new thera...